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- British Society of Echocardiography
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- European Society for Endocrinology
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- Mother’s hormone levels predict child’s ability to do maths
- Hyperthyroidism could be great cost to countries in disability benefits
- Injection of appetite gene may offer a more effective alternative to dieting
- Breast cancer risk higher in women with overactive thyroid
- Diabetes associated with increased risk of serious bacterial blood infection
- Vitamin D pill a day may improve exercise performance and lower risk of heart disease
- Soybean foods may protect menopausal women against osteoporosis
- Bursts of high-intensity exercise could help diabetes patients manage low blood sugar levels
- Enzyme potential target for fight against obesity and diabetes
- New drug provides safer alternative to conventional IVF treatment
- Sitting down for long periods when pregnant linked to weight gain and depression
- New recommendations for the diagnosis and treatment of Adrenal Incidentalomas published in the European Journal of Endocrinology
- Third of pregnant women iron deficient; risk thyroid-related pregnancy complications
- Happy cows make more nutritious milk
- Age-related scarring in ovaries may explain reproductive decline
- Consuming more than two soft drinks a day can double risk of diabetes
- Just six months of frequent exercise improves men’s sperm quality
- New nanotechnology application for difficult-to-treat cancers
- Breast cancer risk is more affected by total body fat than abdominal fat
- Vitamin D supplements could help pain management
- Treating PCOS with a combination of oral contraceptives and spironolactone does not increase the risk of diabetes or heart disease
- International collaboration release revised guideline for improved management of Turner syndrome
- Early pregnancy test for cows improves welfare and food production
- High fat diet during childhood may increase PCOS risk later in life
- Link found between morning sickness, smoking and healthy pregnancies
- Taking paracetamol during pregnancy may reduce fertility of daughters
- Guidelines for management of recurrent pituitary tumours recommend new drug as first line treatment
- Warm temperatures can lead to misdiagnosis of diabetes in pregnancy
- Successful male infertility treatment does not lower fertility of sons
- Potential new target for reducing osteoporosis risk in men
- Arthritis drug can lower sugar levels in diabetes
- Over-the-counter antihistamines linked to impaired fertility in men
- Children born to mothers with low vitamin D levels may develop autism-like behaviours
- Brain development disorders in children linked to common environmental toxin exposures
- Could intermittent fasting diets increase diabetes risk?
- Minimising exposure to common hormone-disrupting chemicals may reduce obesity rates
- Brain stimulation may reduce food cravings as obesity treatment
- Larger waistlines are linked to higher risk of vitamin D deficiency
- Transgender brains are more like their desired gender from an early age
- Walking a tightrope: universal thyroid testing could reduce pregnancy problems in some cases, but interfere with healthy pregnancies in others
- New link identified between inflammation and depression in type-1 diabetes
- Lord Robert Winston cautions that advances in infertility therapies may be hindered by over-regulation
- Bad habits in childhood may lead to an ‘unhealthy’ balance of gut bacteria and increase health risks in later life
- Vitamin B supplements may protect kidney function in children with diabetes
- Vitamin D supplements may promote weight loss in obese children
- Too much vitamin A may increase risk of bone fractures
- Diabetic patients are more at risk of death from alcohol, accidents and suicide
- Oestrogens in cows’ milk are unlikely to pose a threat to adult health
- Women more resilient to extreme physical activity than previously reported
- Good nutrition could protect children from cognitive difficulties caused by early-life stress
- Routine vitamin B12 screening may prevent irreversible nerve damage in type-2 diabetes
- Debate - Is the gut or the brain more important in regulating appetite and metabolism?
- Skin inflammation may increase your risk of type-2 diabetes
- Antioxidants may prevent cognitive impairment in diabetes
- Mentally tiring work may increase diabetes risk in women
- Obesity risk may be increased by exposure to common environmental chemicals
- Breastfeeding reduces long-term risk of heart disease in mothers
- Setting fair regulations for top female athletes that have naturally higher testosterone levels
- Environmental toxins can impair sexual development and fertility of future generations
- Sleep problems in teenagers reversed in just one week by limiting screen use
- Men ignore serious health risks of steroid abuse in pursuit of the body beautiful
- Protective effect of breastfeeding on childhood obesity risk linked to leptin gene modification
- Smoking during pregnancy may damage daughters’ future fertility
- Probiotic supplements may enhance weight loss in obese children
- Limiting mealtimes may increase your motivation for exercise
- Age is not a barrier to the benefits of weight-loss surgery
- New insights into cause and treatments for aggressive form of breast cancer
- Stress with disrupted body clock increases risk of metabolic disease
- Impaired liver function during pregnancy may increase risk of childhood obesity
- Vitamin B12 deficiency linked to obesity during pregnancy
- Common anti-inflammatory may increase risk of diabetes
- Mindfulness helps obese children lose weight
- Larger thighs associated with lower risk of heart disease in obesity
- COVID-19 severity is increased in patients with mild obesity
- Thyroid inflammation linked to anxiety disorders
- Evaluating hormone-related targets & risks associated with COVID-19
- Ghrelin may be an effective treatment for age-related muscle loss
- Probiotics may help manage childhood obesity
- Skin lightening products linked to altered steroid hormone levels
- Vitamin D levels in the blood can predict future health risks & death
- COVID-19 infection may impair fertility in men
- Obesity is linked to heavy periods and impaired womb repair
Vitamin D levels in the blood can predict future health risks & death
Free, circulating vitamin D levels in the blood may be a better predictor of future health risks in aging men, according to a study being presented at e-ECE 2020. These data suggest the free, precursor form of vitamin D found circulating in the bloodstream is a more accurate predictor of future health and disease risk, than the often measured total vitamin D. Since vitamin D deficiency is associated with multiple serious health conditions as we get older, this study suggests that further investigation into vitamin D levels and their link to poor health may be a promising area for further research.
Vitamin D deficiency is common in Europe, especially in elderly people. It has been associated with a higher risk for developing many aging-related diseases, such as cardiovascular disease, cancer and osteoporosis. However, there are several forms, or metabolites, of vitamin D in the body but it is the total amount of these metabolites that is most often used to assess the vitamin D status of people. The prohormone, 25-dihydroxyvitamin D is converted to 1,25-dihydroxyvitamin D, which is considered the active form of vitamin D in our body. More than 99% of all vitamin D metabolites in our blood are bound to proteins, so only a very small fraction is free to be biologically active. Therefore the free, active forms may be a better predictor of current and future health.
Dr Leen Antonio from University Hospitals Leuven in Belgium and a team of colleagues investigated whether the free metabolites of vitamin D were better health predictors, using data from the European Male Ageing Study, which was collected from 1,970 community-dwelling men, aged 40-79, between 2003 and 2005. The levels of total and free metabolites of vitamin D were compared with their current health status, adjusting for potentially confounding factors, including age, body mass index, smoking and self-reported health. The total levels of both free and bound vitamin D metabolites were associated with a higher risk of death. However, only free 25-hydroxyvitamin D was predictive of future health problems and not free 1,25-dihydroxyvitamin D.
Dr Antonio explains, “These data further confirm that vitamin D deficiency is associated with a negative impact on general health and can be predictive of a higher risk of death.”
As this is an observational study, the causal relationships and underlying mechanisms remain undetermined. It was also not possible to obtain specific information about the causes of death of the men in the study, which may be a confounding factor.
“Most studies focus on the association between total 25-hydroxyvitamin D levels and age-related disease and mortality. As 1,25-dihydroxyvitamin D is the active form of vitamin D in our body, it was possible it could have been a stronger predictor for disease and mortality. It has also been debated if the total or free vitamin D levels should be measured. Our data now suggest that both total and free 25-hydroxyvitamin D levels are the better measure of future health risk in men,” says Dr Antonio
Dr Antonio and her team are currently finalising the statistical analysis and writing a manuscript on these findings.
Free 25-hydroxyvitamin D, but not free 1.25-dihydroxyvitamin D, predicts all-cause mortality in ageing men
Leen Antonio, Marian Dejaeger, Roger Bouillon, Frederick Wu, Terence O'neill, Stephen Pye, Ilpo Huhtaniemi, Giulia Rastrelli, Gianni Forti, Felipe Casanueva, Jolanta Slowikowska-Hilczer, Margus Punab, Jos Tournoy, Dirk Vanderschueren, University Hospitals Leuven, Kuleuven, University of Manchester, Imperial College London, University of Florence, Universidad de Santiago de Compostela, Medical University of Łódź, Tartu University
Background: Total 25 hydroxyvitamin D (25(OH)D) and total 1.25 dihydroxyvitamin D (1.25(OH)2D) are associated with all-cause mortality. The free hormone hypothesis postulates that only the free vitamin D fraction can exert its biological function. Recently some studies suggested that free 25(OH)D levels might be a better predictor for clinical outcomes, including mortality.
Objective: To study the association between total and free 25(OH)D and 1.25(OH)2D with all-cause mortality in a prospective cohort of community-dwelling European men.
Methods: 1970 community-dwelling men, aged 40-79, participated in the European Male Ageing Study (EMAS) between 2003-2005. In 5 of 8 EMAS centres, survival status was available until 1 April 2018. Total 25(OH)D levels were measured by radioimmunoassay and recalibrated to NIST standard reference material. Total 1.25(OH)2D was measured by mass spectrometry and vitamin D binding protein (DBP) by immunodiffusion. Free 25(OH)D and free 1.25(OH)2D were calculated from the total hormone and DBP concentration. Vitamin D measurements and DBP were divided into quintiles. Cox proportional hazard models were used to study the association between vitamin D status and all-cause mortality. Because of the wide age range at inclusion, age was used as time scale instead of years since inclusion adjusting for age. Results were expressed as hazard ratios (HR) with 95% confidence intervals, adjusted for centre, BMI, smoking and self-reported health.
Results: 524 (26.6%) men died during a mean follow-up of 12.3±3.4 years. Men who died had a higher BMI (p=0.002) and lower physical activity level (p<0001), but there was no difference in smoking status. Men in the lowest total 25(OH)D and the lowest total 1.25(OH)2D quintile (cutoff <9.3 μg/L and <46 ng/L respectively) had increased mortality risk (HR compared to men in the highest quintile (HR 1.83 (95%CI 1.34-2.50); p<0.001 and 1.41 (1.04-1.90); p<0.05 respectively). Likewise, men in the lowest three free 25(OH)D quintiles (levels <4.43 ng/L) had a higher mortality risk compared to men in the highest quintile (HR 1.91 (1.34-2.73); p<0.001 for the lowest quintile). However, mortality risk was similar for across all free 1.25(OH)2D and DBP quintiles.
Conclusions: Low total 25(OH)D levels and low total 1.25(OH)2D levels in community-dwelling middle-aged and elderly men have an increased future mortality risk. However, only low free 25(OH)D but not free 1.25(OH)2D levels predict all-cause mortality. Vitamin D deficiency is associated with a negative impact on general health and is predictive of a higher mortality risk.
Notes for Editors
The poster “Free 25-hydroxyvitamin D, but not free 1.25-dihydroxyvitamin D, predicts all-cause mortality in ageing men” was presented on Monday 7 September 2020, online during e-ECE 2020.
e-ECE 2020 was held online on the 5-9 September. Catch up on ESE On-Demand.
The European Society of Endocrinology was created to promote research, education and clinical practice in endocrinology by the organisation of conferences, training courses and publications, by raising public awareness, liaison with national and international legislators, and by any other appropriate means.