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- Event Management
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- British Society of Echocardiography
- British Society for Paediatric Endocrinology and Diabetes
- European Society for Endocrinology
- European Society for Paediatric Endocrinology
- European Thyroid Association
- Society for Endocrinology
- Society for Reproduction and Fertility
- UK and Ireland Neuroendocrine Tumour Society
- Mother’s hormone levels predict child’s ability to do maths
- Hyperthyroidism could be great cost to countries in disability benefits
- Injection of appetite gene may offer a more effective alternative to dieting
- Breast cancer risk higher in women with overactive thyroid
- Diabetes associated with increased risk of serious bacterial blood infection
- Vitamin D pill a day may improve exercise performance and lower risk of heart disease
- Soybean foods may protect menopausal women against osteoporosis
- Bursts of high-intensity exercise could help diabetes patients manage low blood sugar levels
- Enzyme potential target for fight against obesity and diabetes
- New drug provides safer alternative to conventional IVF treatment
- Sitting down for long periods when pregnant linked to weight gain and depression
- New recommendations for the diagnosis and treatment of Adrenal Incidentalomas published in the European Journal of Endocrinology
- Third of pregnant women iron deficient; risk thyroid-related pregnancy complications
- Happy cows make more nutritious milk
- Age-related scarring in ovaries may explain reproductive decline
- Consuming more than two soft drinks a day can double risk of diabetes
- Just six months of frequent exercise improves men’s sperm quality
- New nanotechnology application for difficult-to-treat cancers
- Breast cancer risk is more affected by total body fat than abdominal fat
- Vitamin D supplements could help pain management
- Treating PCOS with a combination of oral contraceptives and spironolactone does not increase the risk of diabetes or heart disease
- International collaboration release revised guideline for improved management of Turner syndrome
- Early pregnancy test for cows improves welfare and food production
- High fat diet during childhood may increase PCOS risk later in life
- Link found between morning sickness, smoking and healthy pregnancies
- Taking paracetamol during pregnancy may reduce fertility of daughters
- Guidelines for management of recurrent pituitary tumours recommend new drug as first line treatment
- Warm temperatures can lead to misdiagnosis of diabetes in pregnancy
- Successful male infertility treatment does not lower fertility of sons
- Potential new target for reducing osteoporosis risk in men
- Arthritis drug can lower sugar levels in diabetes
- Over-the-counter antihistamines linked to impaired fertility in men
- Children born to mothers with low vitamin D levels may develop autism-like behaviours
- Brain development disorders in children linked to common environmental toxin exposures
- Could intermittent fasting diets increase diabetes risk?
- Minimising exposure to common hormone-disrupting chemicals may reduce obesity rates
- Brain stimulation may reduce food cravings as obesity treatment
- Larger waistlines are linked to higher risk of vitamin D deficiency
- Transgender brains are more like their desired gender from an early age
- Walking a tightrope: universal thyroid testing could reduce pregnancy problems in some cases, but interfere with healthy pregnancies in others
- New link identified between inflammation and depression in type-1 diabetes
- Lord Robert Winston cautions that advances in infertility therapies may be hindered by over-regulation
- Bad habits in childhood may lead to an ‘unhealthy’ balance of gut bacteria and increase health risks in later life
- Vitamin B supplements may protect kidney function in children with diabetes
- Vitamin D supplements may promote weight loss in obese children
- Too much vitamin A may increase risk of bone fractures
- Diabetic patients are more at risk of death from alcohol, accidents and suicide
- Oestrogens in cows’ milk are unlikely to pose a threat to adult health
- Women more resilient to extreme physical activity than previously reported
- Good nutrition could protect children from cognitive difficulties caused by early-life stress
- Routine vitamin B12 screening may prevent irreversible nerve damage in type-2 diabetes
- Debate - Is the gut or the brain more important in regulating appetite and metabolism?
- Skin inflammation may increase your risk of type-2 diabetes
- Antioxidants may prevent cognitive impairment in diabetes
- Mentally tiring work may increase diabetes risk in women
- Obesity risk may be increased by exposure to common environmental chemicals
- Breastfeeding reduces long-term risk of heart disease in mothers
- Setting fair regulations for top female athletes that have naturally higher testosterone levels
- Environmental toxins can impair sexual development and fertility of future generations
- Sleep problems in teenagers reversed in just one week by limiting screen use
- Men ignore serious health risks of steroid abuse in pursuit of the body beautiful
- Protective effect of breastfeeding on childhood obesity risk linked to leptin gene modification
- Smoking during pregnancy may damage daughters’ future fertility
- Probiotic supplements may enhance weight loss in obese children
- Limiting mealtimes may increase your motivation for exercise
- Age is not a barrier to the benefits of weight-loss surgery
- New insights into cause and treatments for aggressive form of breast cancer
- Stress with disrupted body clock increases risk of metabolic disease
- Impaired liver function during pregnancy may increase risk of childhood obesity
- Vitamin B12 deficiency linked to obesity during pregnancy
- Common anti-inflammatory may increase risk of diabetes
- Mindfulness helps obese children lose weight
- Larger thighs associated with lower risk of heart disease in obesity
- COVID-19 severity is increased in patients with mild obesity
- Thyroid inflammation linked to anxiety disorders
- Evaluating hormone-related targets & risks associated with COVID-19
- Ghrelin may be an effective treatment for age-related muscle loss
- Probiotics may help manage childhood obesity
- Skin lightening products linked to altered steroid hormone levels
- Vitamin D levels in the blood can predict future health risks & death
- COVID-19 infection may impair fertility in men
- Obesity is linked to heavy periods and impaired womb repair
Evaluating hormone-related targets & risks associated with COVID-19
The evidence for hormone involvement in COVID-19 infection and treatment will be evaluated and discussed by endocrine experts in a dedicated COVID-19 session at e-ECE 2020. The European Society of Endocrinology’s annual meeting is going online 5-9 September 2020 and the e-ECE 2020 programme will feature cutting-edge science and the latest in clinical practice and patient care. This includes a new, dedicated COVID-19 session, where experts in the field will present, summarise and examine evidence for the role of the endocrine system and hormones in COVID-19 infection risk, disease severity and potential treatment.
The global COVID-19 pandemic has massively affected how we all live and work and has become the major focus of medical research, as the scientific and medical communities strive to understand it better, develop effective treatments and create a vaccine. This has led to a huge volume of studies being pushed out to the public domain, including some that have not been subject the usual rigorous, scrutiny of peer review. This has resulted in conflicting messages in the media and has contributed to mistrust of experts.
Although initially thought to be a respiratory, influenza-like condition, several studies have now implicated that the severity of COVID-19 infection is increased in people with cardiovascular disease, diabetes and obesity. This raises the possibility that the consequences of viral infection are being affected by the endocrine system. Additionally, severe illness is more common in men, further suggesting that sex, possibly male and female sex hormones, are affecting coronavirus infection. More recently the glucocorticoid, dexamethasone, has shown promise as a treatment in severely ill patients with COVID-19. All of these findings indicate a key role for the endocrine system in mediating infection, disease severity and as a possible therapeutic target.
In the dedicated COVID-19 session at 16:45 CET on 8 September, three experts will review the evidence for the endocrine system’s role in SARS-C0V-2 infection, and discuss how to mitigate these risks, with a view to better managing future cases and saving more lives.
- Daniel Drucker will discuss, ‘Endocrine targets related to COVID infection’
Julia Prado will discuss, ‘Managing the cytokine storm’
- Matteo Rottoli will discuss, ‘How strong is obesity as a risk factor for COVID-19 patients?’
These sessions aim to critically evaluate the role of the endocrine system and endocrinology in the COVID-19 pandemic, with expert debate and hopes of identifying new protective strategies and treatment options, to reduce the disease severity and risk of death in the future.
Endocrine Targets related to COVID19 Infection
Daniel J. Drucker, Tanenbaum Research Institute, Mt. Sinai Hospital, Canada
SARS-CoV-2 infection produces greater morbidity and mortality in people with cardiovascular disease, diabetes, and obesity, raising the possibility that the consequences of viral infection are modulated directly and indirectly by the endocrine system.
Hospitalization and severity of illness is more common in males, further suggesting that sex, possibly male and female sex hormones, modifies the host response to coronavirus infection. SARS-Co-V-2 cellular infection requires ACE2, as well as associated proteases, including TMPRSS2. These molecules are widely expressed in cardiometabolic organs, and the gastrointestinal tract, and to a lesser extent, in the endocrine and exocrine pancreas. Notably, TMPRSS2 is regulated by sex steroids, and clinical trials are examining whether disruption of steroid control of TMPRSS2 expression might be therapeutically useful in SARS-CoV-2 infection, Viral infection may also modify the host susceptibility to autoimmune disease, through dysregulation of humoral and cellular immunity and cytokine expression.
Although SARS-CoV-2 infection has not been associated with widespread endocrine dysfunction beyond that commonly seen with critical illness, case reports of automimmune endocrine disease, including type 1 diabetes, have been described. The use of dexamethasone in severely ill individuals with SARS-CoV-2 prompts evaluation of potential endocrine consequences ensuing from sustained high dose glucocorticoid administration. Herein I will review the endocrine consequences of SARS-C0V-2 infection, highlight key knowns and unknowns, and discuss principles for linking coronavirus infection to disorders of the endocrine system.
How strong is obesity as a risk factor for COVID-19 patients?
Matteo Rottoli MD, PhD, Surgery of the Alimentary Tract, Sant'Orsola Hospital, Alma Mater Studiorum University of Bologna, Italy
Specific comorbidities and old age create a greater vulnerability to severe Coronavirus Disease 19 (COVID-19). While obesity seems to aggravate the course of disease, the actual impact of the body mass index (BMI) and the cut-off which increases illness severity are still under investigation. The aim of the study was to analyze whether the BMI represented a risk factor for respiratory failure, admission to the intensive care unit (ICU) and death.
Research Design and Methods
A retrospective cohort study of 482 consecutive COVID-19 patients hospitalised between March 1 and April 20, 2020. Logistic regression analysis and Cox proportion Hazard models including demographic characteristics and comorbidities were carried out to predict the endpoints within 30 days from the onset of symptoms.
Of the 482 patients included in the study, 202 (41.9%) had a BMI < 25 kg/m2, 176 (36.5%) had a BMI between 25 and 29.9 kg/m2, and 104 (21.6%) were obese (BMI ≥ 30 kg/m2). In the group with obesity, 20 patients (4.1%) had a BMI ≥ 35 kg/m2. A total of 18 patients (3.7%) had a BMI < 20 kg/m2. Hypertension and type 2 diabetes were reported in 76 (72.8%) and 27 (26%) patients with a BMI ≥ 30 kg/m2, respectively. Among patients with obesity, 54 (51.9%) experienced respiratory failure, 38 (36.4%) were admitted to the ICU, 26 (25%) required mechanical ventilation, and 31 (29.8%) died within 30 days from the onset of symptoms. At logistic regression analysis, a BMI between 30 and 34.9 kg/m2 significantly increased the risk of respiratory failure (OR: 2.32; 95% CI: 1.31-4.09, p=0.004), and admission to the ICU (OR: 4.96; 95% CI: 2.53-9.74, p<0.001). A significantly higher risk of death was observed in patients with a BMI ≥ 35 kg/m2 (OR: 12.1; 95% CI: 3.25-45.1, p<0.001).
Obesity is a strong, independent risk factor for respiratory failure, admission to the ICU and death among COVID-19 patients. Whereas a BMI ≥ 30 kg/m2 identifies a population of patients at high risk for severe illness, a BMI ≥ 35 kg/m2 dramatically increases the risk of death.
Notes for Editors
The live COVID-19 Session was held at 16:45 – 18:15 CET, on 8 September 2020, online during e-ECE 2020.
e-ECE 2020 was held online on the 5-9 September. Catch up on ESE On-Demand.
The European Society of Endocrinology was created to promote research, education and clinical practice in endocrinology by the organisation of conferences, training courses and publications, by raising public awareness, liaison with national and international legislators, and by any other appropriate means.