NEWS AND PRESS RELEASES

Probiotic supplements may enhance weight loss in obese children

Sep 2019

Probiotic supplements may enhance weight loss and improve the metabolic health of obese children following a diet and exercise plan, according to research presented today at the 58th Annual European Society for Paediatric Endocrinology Meeting. The findings of this small trial suggest that probiotic supplements may help obese children lose body weight and also reduce their risk of future metabolic conditions, including type 2 diabetes and heart disease.

Obesity in childhood and adolescence represents a major, growing, health problem worldwide, which can lead to the development of expensive, serious and debilitating complications, including heart disease and type 2 diabetes. Probiotics are live microorganisms thought to have health benefits through improving or restoring the diversity of our gut bacteria, also known as the microbiome. Although some studies have reported benefits of probiotic consumption for health and weight loss in adults, its effectiveness has not been fully investigated in obese children.

In this study, Professor Rui-Min Chen and colleagues at Fuzhou Children’s Hospital of Fujian Province, China, conducted a randomised, double-blind trial of probiotic effects on the health of obese children, aged 6-14 years old. All 54 study participants were following a reduced-calorie diet combined with an exercise regime. Their body weight and markers of metabolic health (blood lipid levels, blood glucose levels, insulin levels and inflammatory markers) were measured before and at the end of the 12 week study. Children treated with probiotic supplements lost significantly more weight and had lower levels of markers that indicate poor metabolic health.

Prof Chen states, “Our findings suggest that probiotic supplementation may help with weight loss and improve metabolic health in obese children, and that this may be an effective strategy for the prevention and treatment of obesity in the future.”

Although Prof Chen, cautions, “More work is needed to confirm these findings, our number of participants was small and limited to the Fuijan area. Other studies have also reported no benefits from probiotic treatment in obese children but these were much shorter in duration. So, further investigation is needed before any medical recommendations can be made.”

The team now plan to conduct larger trials examining the effect of probiotics on the metabolic health of obese children, and to extend their investigations to analyse how they alter the gut, with the aim of better understanding the link between gut bacteria and obesity risk.

Prof Chen comments, “Childhood obesity is a growing problem that needs early intervention to prevent long-term health problems; microbiome-based treatments could be a new and more effective strategy for tackling this serious epidemic."

--------ENDS-------

Abstract

Effect of Probiotics intake on obese children
Ruimin Chen, Zhuanzhuan Ai, Xiaohong Yang, Ying Zhang, Xin Yuan
Fuzhou Children’s Hospital of Fujian Province, Fuzhou, China

Background: Childhood obesity has been a worrisome public health issues today. Recent studies conducted in adult populations and animals have suggested beneficial effects of probiotics on obesity, while, the experience is limited in the pediatric age group and the results are conflicted.

Object: The primary objective was to determine the effect of probiotic consumption on weight change. The secondary objective was to determine the effect of the treatment on levels of inflammatory cytokines, serum lipid profile and glucose metabolism.

Methods: This randomized double-blind trial was conducted among obese children aged 6 to 14 years old. They were randomly allocated to receive probiotic capsule (containing Bifidobacterium longum, Lactobacillus bulgaricus and Streptococcus thermophilus) for 12 weeks. All of them were treated with reduced calorie intake and increased physical activity. The anthropometric, inflammatory cytokines, blood lipids and fasting blood glucose, insulin were measured at both baseline and at the end of the study.

Result:
1) A total of 54 obese children participate in the study. 30 were randomized to the probiotic group (19 boys and 11 girls, mean age 9.88±1.79 years, mean BMI 25.73±3.71 kg/m2) and 24 were randomized to the placebo control group(15 boys and 9 girls, mean age 9.60±2.07 years, mean BMI 25.35±3.57 kg/m2).

2) Compared to control group, probiotic consumption significantly reduced Body Mass Index (BMI), inflammatory markers (interleukin-6, lipopolysaccharide binding protein, tumor necrosis factor α), triglyceride, fasting blood glucose, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) (P < 0.05).

Conclusion: Receiving 12 weeks probiotic supplement can improve body mass index as well as components of the inflammatory and glycolipid metabolism. Additionally, to the best of our knowledge, this is the first study showing the effects of probiotic on lipopolysaccharide binding protein in obese children.

Notes for editors:

The study “Effect of Probiotics intake on obese children” was presented by Prof Rui-Min Chen on Friday 20 September (abstract P1-191), at the 58th Annual European Society for Paediatric Endocrinology Meeting in Vienna, Austria.

The 58th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2019 Meeting) is held 19-21 September 2019 in Vienna, Austria. The ESPE annual meeting is recognised worldwide as being of high scientific and educational quality.

The European Society for Paediatric Endocrinology (ESPE) is a truly international organisation aiming to improve the clinical care of children and adolescents with endocrine conditions, including diabetes, through research and education. www.eurospe.org

 

 

Press

Larger thighs associated with lower risk of heart disease in obesity
Mindfulness helps obese children lose weight
Common anti-inflammatory may increase risk of diabetes
Vitamin B12 deficiency linked to obesity during pregnancy
Impaired liver function during pregnancy may increase risk of childhood obesity
Stress with disrupted body clock increases risk of metabolic disease
New insights into cause and treatments for aggressive form of breast cancer
Age is not a barrier to the benefits of weight-loss surgery
Limiting mealtimes may increase your motivation for exercise
Probiotic supplements may enhance weight loss in obese children
Smoking during pregnancy may damage daughters’ future fertility
Protective effect of breastfeeding on childhood obesity risk linked to leptin gene modification
Setting fair regulations for top female athletes that have naturally higher testosterone levels
Environmental toxins can impair sexual development and fertility of future generations
Sleep problems in teenagers reversed in just one week by limiting screen use
Men ignore serious health risks of steroid abuse in pursuit of the body beautiful
Obesity risk may be increased by exposure to common environmental chemicals
Breastfeeding reduces long-term risk of heart disease in mothers
Mentally tiring work may increase diabetes risk in women
Antioxidants may prevent cognitive impairment in diabetes
Skin inflammation may increase your risk of type-2 diabetes
Debate - Is the gut or the brain more important in regulating appetite and metabolism?
Routine vitamin B12 screening may prevent irreversible nerve damage in type-2 diabetes
Good nutrition could protect children from cognitive difficulties caused by early-life stress
Women more resilient to extreme physical activity than previously reported
Oestrogens in cows’ milk are unlikely to pose a threat to adult health
Diabetic patients are more at risk of death from alcohol, accidents and suicide
Too much vitamin A may increase risk of bone fractures
Vitamin D supplements may promote weight loss in obese children
Vitamin B supplements may protect kidney function in children with diabetes
Bad habits in childhood may lead to an ‘unhealthy’ balance of gut bacteria and increase health risks in later life
Lord Robert Winston cautions that advances in infertility therapies may be hindered by over-regulation
New link identified between inflammation and depression in type-1 diabetes
Walking a tightrope: universal thyroid testing could reduce pregnancy problems in some cases, but interfere with healthy pregnancies in others
Brain stimulation may reduce food cravings as obesity treatment
Larger waistlines are linked to higher risk of vitamin D deficiency
Transgender brains are more like their desired gender from an early age
Could intermittent fasting diets increase diabetes risk?
Minimising exposure to common hormone-disrupting chemicals may reduce obesity rates
Brain development disorders in children linked to common environmental toxin exposures
Children born to mothers with low vitamin D levels may develop autism-like behaviours
Over-the-counter antihistamines linked to impaired fertility in men
Arthritis drug can lower sugar levels in diabetes
Potential new target for reducing osteoporosis risk in men
Successful male infertility treatment does not lower fertility of sons
Warm temperatures can lead to misdiagnosis of diabetes in pregnancy
Guidelines for management of recurrent pituitary tumours recommend new drug as first line treatment
Taking paracetamol during pregnancy may reduce fertility of daughters
Link found between morning sickness, smoking and healthy pregnancies
High fat diet during childhood may increase PCOS risk later in life
Early pregnancy test for cows improves welfare and food production
International collaboration release revised guideline for improved management of Turner syndrome
Treating PCOS with a combination of oral contraceptives and spironolactone does not increase the risk of diabetes or heart disease
Vitamin D supplements could help pain management
Breast cancer risk is more affected by total body fat than abdominal fat
New nanotechnology application for difficult-to-treat cancers
Just six months of frequent exercise improves men’s sperm quality
Consuming more than two soft drinks a day can double risk of diabetes
Age-related scarring in ovaries may explain reproductive decline
Happy cows make more nutritious milk
Third of pregnant women iron deficient; risk thyroid-related pregnancy complications
New recommendations for the diagnosis and treatment of Adrenal Incidentalomas published in the European Journal of Endocrinology
Sitting down for long periods when pregnant linked to weight gain and depression
New drug provides safer alternative to conventional IVF treatment
Enzyme potential target for fight against obesity and diabetes
Bursts of high-intensity exercise could help diabetes patients manage low blood sugar levels
Soybean foods may protect menopausal women against osteoporosis
Vitamin D pill a day may improve exercise performance and lower risk of heart disease
Diabetes associated with increased risk of serious bacterial blood infection
Breast cancer risk higher in women with overactive thyroid
Injection of appetite gene may offer a more effective alternative to dieting
Hyperthyroidism could be great cost to countries in disability benefits
Mother’s hormone levels predict child’s ability to do maths