NEWS AND PRESS RELEASES

Vitamin B supplements may protect kidney function in children with diabetes

Sep 2018

Vitamin B supplements have a protective effect on kidney function in children and adolescents with type-1 diabetes, according to research presented today at the 57th Annual European Society for Paediatric Endocrinology Meeting. These findings indicate that simple supplementation of vitamin B complex may protect against the development and progression of kidney disease in children with diabetes, which could promote improved health and quality of life in adulthood.

Type-1 diabetes is a life-long disease in which the body does not make enough insulin to regulate blood glucose levels. The condition is usually diagnosed in childhood and can lead to serious and debilitating complications, including diabetic kidney disease. This common complication develops over many years, but has no symptoms in the early stages, so if undetected can necessitate long-term, intensive or expensive treatments, and lead to earlier death in adulthood. Vitamin B deficiency is associated with an increased risk of kidney damage and is often observed in children and adults with type-1 diabetes. However, whether supplements can improve blood glucose regulation or kidney function in vitamin B deficient type-1 diabetic children had not yet been fully investigated.

In this study by Prof Nancy Samir Elbarbary and colleagues at Ain Shams University in Cairo, 80 vitamin B12-deficient, type-1 diabetics, aged 12-18 years, with early signs of diabetic kidney disease were given either vitamin B supplements or no treatment, over a 12-week period. After 12 weeks, the children given vitamin B supplements showed significant changes in several blood markers that overall indicated improvements in their blood glucose regulation and kidney function.

Prof Elbarbary states, “After 12 weeks of vitamin B complex supplementation in children and adolescents with diabetic kidney disease, we detected lower levels of markers that indicate poor kidney function, suggesting that it had a protective effect and could slow progression of the disease.”

Prof Elbarbary, comments, “Although the best strategy for treating diabetic kidney disease is prevention, for example through better blood glucose control and maintenance of healthy blood pressure, a normal lipid profile and a healthy body weight, the long-term duration of diabetes still increases the risk of developing kidney disease. So, these findings suggest vitamin B supplementation, in addition to traditional angiotensin converting enzyme inhibitor therapy may be a simple, safe and cost-effective strategy for early protection of kidney function, which may improve the long-term quality of life for type-1 diabetes patients.”

Although Prof Elbarbary also cautions, “This was a relatively small study and these findings still need to be confirmed in larger, multicentre randomised trials to verify the role of vitamin B complex supplementation in treating early diabetic kidney disease over longer periods of time, but these early results are a promising start."

----ENDS----


Notes for Editors

The study “Effect of Homocysteine-Lowering Therapy on Diabetic Nephropathy in children and adolescents with Type 1 Diabetes” (abstract FC12.5), was presented at the 57th Annual European Society for Paediatric Endocrinology Meeting in Athens, Greece.

The 57th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE 2018 Meeting) was held 27-29 September 2018 in Athens, Greece. The ESPE annual meeting is recognised worldwide as being of high scientific and educational quality. www.eurospe.org 

Press

Obesity risk may be increased by exposure to common environmental chemicals
Setting fair regulations for top female athletes that have naturally higher testosterone levels
Environmental toxins can impair sexual development and fertility of future generations
Sleep problems in teenagers reversed in just one week by limiting screen use
Men ignore serious health risks of steroid abuse in pursuit of the body beautiful
Breastfeeding reduces long-term risk of heart disease in mothers
Mentally tiring work may increase diabetes risk in women
Antioxidants may prevent cognitive impairment in diabetes
Skin inflammation may increase your risk of type-2 diabetes
Debate - Is the gut or the brain more important in regulating appetite and metabolism?
Routine vitamin B12 screening may prevent irreversible nerve damage in type-2 diabetes
Good nutrition could protect children from cognitive difficulties caused by early-life stress
Women more resilient to extreme physical activity than previously reported
Oestrogens in cows’ milk are unlikely to pose a threat to adult health
Diabetic patients are more at risk of death from alcohol, accidents and suicide
Too much vitamin A may increase risk of bone fractures
Vitamin D supplements may promote weight loss in obese children
Vitamin B supplements may protect kidney function in children with diabetes
Bad habits in childhood may lead to an ‘unhealthy’ balance of gut bacteria and increase health risks in later life
Lord Robert Winston cautions that advances in infertility therapies may be hindered by over-regulation
New link identified between inflammation and depression in type-1 diabetes
Walking a tightrope: universal thyroid testing could reduce pregnancy problems in some cases, but interfere with healthy pregnancies in others
Brain stimulation may reduce food cravings as obesity treatment
Larger waistlines are linked to higher risk of vitamin D deficiency
Transgender brains are more like their desired gender from an early age
Could intermittent fasting diets increase diabetes risk?
Minimising exposure to common hormone-disrupting chemicals may reduce obesity rates
Brain development disorders in children linked to common environmental toxin exposures
Children born to mothers with low vitamin D levels may develop autism-like behaviours
Over-the-counter antihistamines linked to impaired fertility in men
Arthritis drug can lower sugar levels in diabetes
Potential new target for reducing osteoporosis risk in men
Successful male infertility treatment does not lower fertility of sons
Warm temperatures can lead to misdiagnosis of diabetes in pregnancy
Guidelines for management of recurrent pituitary tumours recommend new drug as first line treatment
Taking paracetamol during pregnancy may reduce fertility of daughters
Link found between morning sickness, smoking and healthy pregnancies
High fat diet during childhood may increase PCOS risk later in life
Early pregnancy test for cows improves welfare and food production
International collaboration release revised guideline for improved management of Turner syndrome
Treating PCOS with a combination of oral contraceptives and spironolactone does not increase the risk of diabetes or heart disease
Vitamin D supplements could help pain management
Breast cancer risk is more affected by total body fat than abdominal fat
New nanotechnology application for difficult-to-treat cancers
Just six months of frequent exercise improves men’s sperm quality
Consuming more than two soft drinks a day can double risk of diabetes
Age-related scarring in ovaries may explain reproductive decline
Happy cows make more nutritious milk
Third of pregnant women iron deficient; risk thyroid-related pregnancy complications
New recommendations for the diagnosis and treatment of Adrenal Incidentalomas published in the European Journal of Endocrinology
Sitting down for long periods when pregnant linked to weight gain and depression
New drug provides safer alternative to conventional IVF treatment
Enzyme potential target for fight against obesity and diabetes
Bursts of high-intensity exercise could help diabetes patients manage low blood sugar levels
Soybean foods may protect menopausal women against osteoporosis
Vitamin D pill a day may improve exercise performance and lower risk of heart disease
Diabetes associated with increased risk of serious bacterial blood infection
Breast cancer risk higher in women with overactive thyroid
Injection of appetite gene may offer a more effective alternative to dieting
Hyperthyroidism could be great cost to countries in disability benefits
Mother’s hormone levels predict child’s ability to do maths