NEWS AND PRESS RELEASES

New link identified between inflammation and depression in type-1 diabetes

Jun 2018

Depression in type-1 diabetes patients is associated with higher levels of the inflammatory protein galectin-3, according to research published in Endocrine Connections. These findings suggest that galectin-3 levels may be useful for diagnosis of depression or may be a new target for treating depression associated with type-1 diabetes, which could lead to better patient care.

It is well established that people with both type-1 and type-2 diabetes have an increased risk of developing depression, a debilitating mental health disorder with potentially serious consequences, but the causes remain poorly understood. Galectin-3 is a key protein involved in promoting inflammatory immune system responses that are needed to repair tissue damage throughout the body, in response to injury or disease. However, elevated levels of galectin-3 have also been linked to an increased risk of inflammatory disorders including Alzheimer’s disease and cardiovascular disease. Previous research has suggested that both depression and diabetes may be associated with increased levels of inflammation in the body but the role of galectin-3 has not been investigated in either condition.

In this study, Dr Eva Olga Melin and colleagues at Lund University in Sweden measured the galectin-3 levels of 283 men and women, aged 18-59, with type-1 diabetes, for at least one year. Incidence of depression in these patients was self-reported and assessed using the Hospital Anxiety and Depression Scale-Depression subscale and possible confounding influences of lifestyle factors including heart disease, smoking or poorly managed diabetes were accounted for in the analysis. The researchers found that both men and women with type-1 diabetes and depression also had significantly higher galectin-3 levels.

Dr Melin comments, “We found that people with type-1 diabetes and depression had higher galectin-3 levels, yet no other diabetes-related metabolic changes could account for these elevated levels.”

The team now plan to further investigate the link between type-1 diabetes, depression and galectin-3, as although these findings indicate that galectin-3 levels are associated with diabetes and depression, they are not sufficient to show any causative relationship. Larger, long-term studies are needed, as well as further analyses investigating how galectin-3 levels are linked to the increased risk of depression, what inflammatory processes are altered, and whether they can be targeted to treat depression.

Dr Melin says, “Depression is a common disorder with very serious and debilitating consequences, so these findings suggest that further investigating the role of galectin-3 could lead to improved diagnosis and maybe better treatment outcomes for patients in the future.”

--------ENDS-------

 

The paper “Depression in type 1 diabetes was associated with high levels of circulating galectin-3” was published in Endocrine Connections in May 2018. 

The journal Endocrine Connections is published by Bioscientifica, an innovative and agile publisher. Bioscientifica collaborates with learned societies worldwide to develop new and existing quality products that meet the ever-changing needs of the biomedical community. Our publishing portfolio includes journals and online resources, including Journal of Endocrinology, Endocrine-Related Cancer, Journal of Molecular Endocrinology, Bone Abstracts and Endocrinology, Diabetes & Metabolism Case Reports. Bioscientifica is a wholly-owned commercial subsidiary of the Society for Endocrinology.

The Society for Endocrinology is a UK-based membership organisation representing a global community of scientists, clinicians and nurses who work with hormones. Together we aim to improve public health by advancing endocrine education and research, and engaging wider audiences with the science of hormones. 

 

Press

Mentally tiring work may increase diabetes risk in women
Antioxidants may prevent cognitive impairment in diabetes
Skin inflammation may increase your risk of type-2 diabetes
Debate - Is the gut or the brain more important in regulating appetite and metabolism?
Routine vitamin B12 screening may prevent irreversible nerve damage in type-2 diabetes
Good nutrition could protect children from cognitive difficulties caused by early-life stress
Women more resilient to extreme physical activity than previously reported
Oestrogens in cows’ milk are unlikely to pose a threat to adult health
Diabetic patients are more at risk of death from alcohol, accidents and suicide
Too much vitamin A may increase risk of bone fractures
Vitamin D supplements may promote weight loss in obese children
Vitamin B supplements may protect kidney function in children with diabetes
Bad habits in childhood may lead to an ‘unhealthy’ balance of gut bacteria and increase health risks in later life
Lord Robert Winston cautions that advances in infertility therapies may be hindered by over-regulation
New link identified between inflammation and depression in type-1 diabetes
Walking a tightrope: universal thyroid testing could reduce pregnancy problems in some cases, but interfere with healthy pregnancies in others
Brain stimulation may reduce food cravings as obesity treatment
Larger waistlines are linked to higher risk of vitamin D deficiency
Transgender brains are more like their desired gender from an early age
Could intermittent fasting diets increase diabetes risk?
Minimising exposure to common hormone-disrupting chemicals may reduce obesity rates
Brain development disorders in children linked to common environmental toxin exposures
Children born to mothers with low vitamin D levels may develop autism-like behaviours
Over-the-counter antihistamines linked to impaired fertility in men
Arthritis drug can lower sugar levels in diabetes
Potential new target for reducing osteoporosis risk in men
Successful male infertility treatment does not lower fertility of sons
Warm temperatures can lead to misdiagnosis of diabetes in pregnancy
Guidelines for management of recurrent pituitary tumours recommend new drug as first line treatment
Taking paracetamol during pregnancy may reduce fertility of daughters
Link found between morning sickness, smoking and healthy pregnancies
High fat diet during childhood may increase PCOS risk later in life
Early pregnancy test for cows improves welfare and food production
International collaboration release revised guideline for improved management of Turner syndrome
Treating PCOS with a combination of oral contraceptives and spironolactone does not increase the risk of diabetes or heart disease
Vitamin D supplements could help pain management
Breast cancer risk is more affected by total body fat than abdominal fat
New nanotechnology application for difficult-to-treat cancers
Just six months of frequent exercise improves men’s sperm quality
Consuming more than two soft drinks a day can double risk of diabetes
Age-related scarring in ovaries may explain reproductive decline
Happy cows make more nutritious milk
Third of pregnant women iron deficient; risk thyroid-related pregnancy complications
New recommendations for the diagnosis and treatment of Adrenal Incidentalomas published in the European Journal of Endocrinology
Sitting down for long periods when pregnant linked to weight gain and depression
New drug provides safer alternative to conventional IVF treatment
Enzyme potential target for fight against obesity and diabetes
Bursts of high-intensity exercise could help diabetes patients manage low blood sugar levels
Soybean foods may protect menopausal women against osteoporosis
Vitamin D pill a day may improve exercise performance and lower risk of heart disease
Diabetes associated with increased risk of serious bacterial blood infection
Breast cancer risk higher in women with overactive thyroid
Injection of appetite gene may offer a more effective alternative to dieting
Hyperthyroidism could be great cost to countries in disability benefits
Mother’s hormone levels predict child’s ability to do maths