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Serono Foundation for the Advancement of Medical Science Workshop on Molecular Steroidogenesis
(24 - 27 April 2003)

Steroids are crucial to a range of important physiological processes (glucose-insulin sensitivity, lipid and salt homeostasis, immune responses, reproduction/pregnancy, digestion, bone growth, mood and memory function) and they are widely exploited as treatments for human disorders. Detailed understanding of the tissue specific pathways of synthesis and degradation of steroids, and the closely related sterols (eg cholesterol), thus affords key insights into their physiological control and also illustrates novel possibilities for their therapeutic manipulation.

The aim of the meeting is to increase understanding of the structure, function and regulation of the enzymes that are involved in sterol/steroid synthesis and metabolism in normal physiology, pathologies, and genetic disorders. The meeting will comprise presentations and discussions from internationally renowned groups that will be invaluable in providing deeper insight into the metabolism, disposition and function of sterols and steroid hormones. In addition to opportunities for registrants to contribute poster presentations, abstract submissions will also be considered for oral presentation in concert with those of invited speakers in the various workshop sessions.

PROPOSED TOPICS:-

  • Structure, function and chemistry of cytochrome P450
  • Steroidogenesis
  • Steroid dehydrogenases
  • Neurosteroids
  • Peripheral sterol/steroid metabolism
  • Non-mammalian steroid biosynthesis
  • Receptor, signalling systems and sterol trafficking
  • Development
  • Degenerative disorders/ageing