It is 100 years since Harvey Cushing described the disease that now bears his name. We are now at a new and exciting phase of understanding and treating Cushing’s disease. This handbook aims to offer easily accessible insights into the clinical, biochemical, and radiological diagnosis of Cushing’s disease, as well as in the current surgical, radiotherapeutic and medical treatments available to these patients.

Chapters:

Clinical diagnosis: signs, symptoms, epidemiology
Günter Karl Stalla, Christina Dimopoulou, Germany

Diagnosis, sampling and imaging
Lynnette K Nieman, USA

Mortality, systemic and psychiatric complications
Annamaria Colao, Monica De Leo, Rosario Pivonello, Gaetano Lombardi, Italy

Quality of life and long-term follow-up
Susan M Webb, Alicia Santos, Eugenia Resmini, Elena Valassi, M’Antonia Martínez, Olga Roig, Iris Crespo, Xavier Badia, Spain

Surgical management and radiotherapy
Michael Buchfelder, Sven Schlaffer, Germany

Definition of clinical remission vs. biochemical remission
John Newell-Price, UK

Medical therapy with ketoconazole and mifepristone
Frederic Castinetti, Thierry Brue, France

Membrane receptors on corticotrophinomas: therapeutic targets
Leo J Hofland, The Netherlands

Medical therapy with dopamine receptor analogues
Rosario Pivonello, Monica De Leo, Alessia Cozzolino, Pasquale Vitale, Maria Cristina De Martino, Annamaria Colao, Italy

Medical therapy with pasireotide
Stephan Petersenn, Germany

Medical combination therapy for Cushing’s disease
Richard A Feelders, The Netherlands

Practical aspects of the management of patients with Cushing’s disease
Josephine I Tuthill, John AH Wass, UK

Future prospects
Steven WJ Lamberts, The Netherlands